کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
923787 | 921127 | 2006 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Stress susceptibility predicts the severity of immune depression and the failure to combat bacterial infections in chronically stressed mice Stress susceptibility predicts the severity of immune depression and the failure to combat bacterial infections in chronically stressed mice](/preview/png/923787.png)
Chronic psychological stress has been suggested to play a role in disorders in which the immune system unexpectedly fails to respond in a protective manner. Chronic combined acoustic and restraint stress compromises the anti-bacterial defense mechanisms of female BALB/c mice. The immunodeficiency is characterized by an apoptotic loss of lymphocytes, reduced ex vivo-inducibility of TNF but increased inducibility of IL10, reduced T-cell proliferation, and impaired phagocyte functions. Stressed mice develop depression-like behavior that was monitored by a stress severity score (SSS). Besides a strain (BALB/c > CBA) and gender (male > female) dependent susceptibility to chronic stress, inbred mice have an individual coping ability. Importantly, the individual SSS strongly correlates with Escherichia coli dissemination after infection as well as with IL10-inducibility and circulating corticosterone levels of each animal.
Journal: Brain, Behavior, and Immunity - Volume 20, Issue 4, July 2006, Pages 359–368