کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9266195 | 1217272 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Homeostatic and functional analysis of mature B cells in λ5-deficient mice
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کلمات کلیدی
PECFSCSSCNIPB1 cellsMarginal zone B cells5-bromo-2′-deoxyuridine - 5-bromo-2'-deoxyuridineBAFF - بافBrdU - بروموداکسی اوریدینthymus-independent - تیوسی مستقلsurrogate light chain - زنجیره سبک جایگزینImmunoglobulin heavy chain - زنجیره سنگین ایمونوگلوبولینperitoneal exudate cells - سلول های اگزودای صفاقیFollicular B cells - سلول های بنیادی فولیکولارthymus-dependent - وابسته به تیماسrelative units - واحدهای نسبیside scatter - پراکندگی سمتforward light scatter - پراکندگی نور رو به جلوPropidium iodide - پروتئین یدیدpre-B cell receptor - گیرنده سلول پیش از ب
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for λ5 gene expression have a block in early B-cell development leading to a markedly reduced number of peripheral B cells. To address the question of how this early developmental block influences the composition of the B-cell pool, we have analyzed mature B-cell subpopulations in λ5-deficient mice. In analogy with other situations of B lymphopenia, the proportion was increased but not the absolute number of marginal-zone B cells, whereas those of follicular B cells were decreased. Immunohistology revealed that B-cell follicles were smaller in overall size and contained a prominent B-cell replete marginal zone. BrdU labelling kinetics showed slower turnover of follicular as well as of marginal-zone B cells. Functionally, λ5â/â mice were able to mount not only primary but also secondary thymus-dependent as well as thymus-independent responses, albeit mostly at reduced levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 101, Issue 2, 15 November 2005, Pages 173-184
Journal: Immunology Letters - Volume 101, Issue 2, 15 November 2005, Pages 173-184
نویسندگان
Eva Harfst, Jan Andersson, Ulf Grawunder, Rod Ceredig, Antonius G. Rolink,