کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9266251 | 1217275 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin 18 (IL-18) upregulation in acute rejection of kidney allograft
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Interleukin 18 (IL-18) is a potent proinflammatory cytokine involved in the host defence by upregulating both innate and acquired immune responses and may be of particular importance also in mechanisms of kidney allograft rejection. Immunohistochemical staining of protocol biopsies showed constitutive IL-18 expression in the epithelium of distal tubules with the induction of immunoreactivity in acute rejection patients where also proximal tubules, infiltrating leukocytes, and endothelium were strongly positive. Furthermore, serum levels of IL-18 were significantly elevated in patients with acute rejection of kidney allograft (1247 ± 389 pg/l) as compared to patients with uncomplicated outcome of kidney transplantation (444 ± 164 pg/l) and subjects with acute tubulointerstitial nephropathy (385 ± 155 pg/l, p < 0.0001 for both comparisons). Tissue culture model of renal epithelial cells expressed IL-18 mRNA constitutively and released mature IL-18 in response to TNF-α and IFN-γ. We assume that upregulation of epithelial IL-18 plays an important role in immune and immunopathological reactions in renal parenchyma and contributes to rejection mechanisms of kidney allograft.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 99, Issue 1, 15 June 2005, Pages 30-35
Journal: Immunology Letters - Volume 99, Issue 1, 15 June 2005, Pages 30-35
نویسندگان
Ilja Striz, Krasna Eliska, Honsova Eva, Lacha Jiri, Petrickova Katerina, Jaresova Marcela, Lodererova Alena, Bohmova Radka, Valhova Sarka, Slavcev Antonij, Vitko Stefan,