کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9266281 1217276 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy
چکیده انگلیسی
Thymidylate synthase (TYMS), the critical enzyme for DNA synthesis and a target for chemotherapy, was recently characterized as an oncogene and a potential target for specific immunotherapy. Here we report TYMS-specific antibody response in a fraction of colon cancer patients. Humoral immune response to TYMS is induced by chemotherapy using TYMS inhibitors, such as 5-fluorouracil (5-FU), and may be associated with tumor burden. Therefore, TYMS may serve as a useful serological biomarker for monitoring the course of disease and treatment in cancer patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 100, Issue 1, 15 August 2005, Pages 88-93
نویسندگان
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