کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9266428 1217285 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development and maturation of Langerhans cells, spleen and bone marrow dendritic cells in TNF-α/lymphotoxin-α double-deficient mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Development and maturation of Langerhans cells, spleen and bone marrow dendritic cells in TNF-α/lymphotoxin-α double-deficient mice
چکیده انگلیسی
Dendritic cells are key regulators of immunity and tolerance. TNF-α has manifold effects on dendritic cells. It is an indispensable ingredient in several dendritic cell generation protocols, especially in the human, and it is included in diverse maturation stimuli for dendritic cells. Mice deficient in various components of the TNF/lymphotoxin system (TNF-α, lymphotoxin-α and -β, TNF receptors, combinations thereof) have profound defects in mounting immune responses to infections. The dendritic cell system in these mice has been incompletely studied to date. We therefore investigated dendritic cells from the epidermis (Langerhans cells), spleen and the bone marrow of mice double-deficient in TNF-α and lymphotoxin-α. We report that dendritic cells in these mice are grossly normal. Langerhans cells, spleen and bone marrow dendritic cells can develop and mature. Their expression of MHC II and CD86 is not impaired, and their T cell-stimulatory as well as antigen-processing capacity is comparable to their normal counterparts. Thus, the described defects in these mice appear to be due the lack of lymph nodes, the disturbed architecture of the spleen, and deranged chemokine production patterns, rather than to a profoundly altered dendritic cell system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 96, Issue 1, 15 January 2005, Pages 109-120
نویسندگان
, , , , , , ,