کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9267926 | 1218814 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anti-ergotypic T cells in naïve rats
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کلمات کلیدی
SPFTCGFAMLRT-cell vaccinationConAEAELNCTCVConcanavalin Aexperimental autoimmune encephalomyelitis - آنسفالومیلیت خودایمنی تجربیAutoimmune diseases - بیماری خودایمنیlymph node cells - سلول های گره لنفاویRegulatory T cells - سلولهای تی تنظیمکنندهSpleen - طحالT lymphocytes - لنفوسیتهای TMycobacterium tuberculosis - مایکوباکتریوم توبرکلوزیسMultiple sclerosis - مولتیپل اسکلروزیس(ام اس)specific pathogen free - پاتوژن خاص رایگان است
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anti-ergotypic T cells in naïve rats Anti-ergotypic T cells in naïve rats](/preview/png/9267926.png)
چکیده انگلیسی
T regulatory cells play an important role in regulating T cell responses. Anti-ergotypic T cells are a subset of regulatory T cells that proliferate in response to activation markers, ergotopes, expressed on activated, and not on resting syngeneic T cells. Here we report the presence of anti-ergotypic T cells in lymph nodes, spleens and thymuses of naïve rats. The development of anti-ergotypic T cells appeared to be independent of antigen priming, as thymocytes from one-day old rats exhibited significant anti-ergotypic proliferative responses. The anti-ergotypic T cells were found to be of the CD8+ phenotype, and included both TCRα/β+ and TCRγ/δ+ T cells. The TCRγ/δ+ anti-ergotypic T cells secreted IFNγ and TNFα in response to activated T cells; the TCRα/β+ T cells proliferated but did not secret detectable cytokines. We found that the interaction between the anti-ergotypic T cells and stimulator T cells required cell-to-cell contact between the T cells. Professional APCs were not needed. The response of the TCRα/β+CD8+ anti-ergotypic T cells was MHC-I restricted and B7-CD28 dependent; the response of the TCRγ/δ+ anti-ergotypic T cells was B7-CD28 dependent, but was not inhibited by antibodies to classical MHC-I or MHC-II molecules. The existence of anti-ergotypic T cells in naïve animals suggests that these cells might have a role in the regulation and maintenance of the immune system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 24, Issue 3, May 2005, Pages 191-201
Journal: Journal of Autoimmunity - Volume 24, Issue 3, May 2005, Pages 191-201
نویسندگان
Avishai Mimran, Felix Mor, Francisco J. Quintana, Irun R. Cohen,