کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9276039 | 1222378 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection](/preview/png/9276039.png)
چکیده انگلیسی
A PCR restriction fragment length polymorphism assay was used to analyse single-nucleotide polymorphisms in the tumour necrosis factor (TNF)-α and TNF-β genes of 56 patients with chronic severe hepatitis B virus (HBV) infection, 71 patients who either had chronic mild HBV infection or who were asymptomatic carriers, and 90 healthy controls. The serum TNF-α concentrations in patients with chronic severe HBV infection were compared to those of 30 healthy controls by radioimmunoassay. The frequencies of the TNF1/2 genotype and the TNF2 allele were greater in patients with chronic severe HBV infection than in healthy controls (25% vs. 11.1%, p 0.015; 12.5% vs. 5.6%, p 0.036, respectively) and patients with chronic mild HBV infection and asymptomatic carriers (25% vs. 8.8%, p 0.011; 12.5% vs. 4.2%, p 0.015, respectively). Heterozygotes carrying the TNF2 allele had higher levels of serum TNFα than homozygotes for the wild-type allele among all patients with chronic severe HBV infection (p < 0.01). The genotype distribution and allele frequency of TNF-β were similar for patients with chronic severe HBV infection and healthy controls, but the frequency of the TNF-β*2/2 genotype in patients with chronic mild HBV infection and asymptomatic controls was lower than for healthy controls (9.9% vs. 22.4%, p 0.043) or patients with chronic severe HBV infection (9.9% vs. 26.8%, p 0.043), although this was not significant after correction for multiple testing. It was concluded that TNF-α gene polymorphisms may play an important role as a host factor in the progression of HBV infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 11, Issue 1, January 2005, Pages 52-56
Journal: Clinical Microbiology and Infection - Volume 11, Issue 1, January 2005, Pages 52-56
نویسندگان
X.-W. Xu, M.-H. Lu, D.-M. Tan,