کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9282893 | 1593662 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Monitoring for human cytomegalovirus infection in solid organ transplant recipients through antigenemia and glycoprotein N (gN) variants: evidence of correlation and potential prognostic value of gN genotypes
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کلمات کلیدی
HCMVNPVGlycoprotein Hglycoprotein MPBLsORFRFLPPPVpositive predictive value - ارزش پیش بینی مثبتnegative predictive value - ارزش پیش بینی منفیHuman cytomegalovirus - سیتومگالوویروس انسانیopen reading frame - قاب خواندن بازperipheral blood leukocytes - لکوسیت های خون محیطیrestriction fragment length polymorphism - پلی مورفیسم طول قطعه قطعهGlycoprotein complex - پیچیده گلیکوپروتئینGenotypes - ژنوتیپGlycoprotein B - گلیکوپروتئین Bsolid organ transplant recipients - گیرندگان بدن پیوند عضو
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Monitoring for human cytomegalovirus infection in solid organ transplant recipients through antigenemia and glycoprotein N (gN) variants: evidence of correlation and potential prognostic value of gN genotypes Monitoring for human cytomegalovirus infection in solid organ transplant recipients through antigenemia and glycoprotein N (gN) variants: evidence of correlation and potential prognostic value of gN genotypes](/preview/png/9282893.png)
چکیده انگلیسی
Human cytomegalovirus (HCMV) ORF UL73 encodes the envelope glycoprotein gpUL73-gN, which shows seven genotypes (gN-1, gN-2, gN-3a, gN-3b, gN-4a, gN-4b, gN-4c). The goal of this study was to determine retrospectively the distribution of gN variants in solid organ transplant recipients with HCMV infection and to establish an association with parameters important for monitoring post-transplantation clinical course during a follow-up of up to 2Â years. Peripheral blood leukocytes from 40 solid organ transplant recipients were analysed for pp65-antigen by immunofluorescence and gN genotyped by sequencing or RFLP analysis. A correlation between gN genotypes and antigenemia peak was found, showing a highly significant difference between gN-1 and gN-4b variants (PÂ <Â 0.005). In particular, gN-1 seems to be associated with patients developing low level antigenemia (<50 pp65-positive cells/2 Ã 105 PBLs; PPV = 90%), whereas gN-4b predicts significantly higher values (>50 pp65-positive cells/2 Ã 105 PBLs; PPV = 80%). Furthermore, the onset of positive antigenemia is significantly earlier in patients infected with a gN-4b strain, compared with those infected by a gN-1 variant. Reported data further support a role for gN genotypes in HCMV pathogenesis. gN-1 and gN-4b show a significantly different virulence and could serve as early predictors for the progression of HCMV infection in transplant patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 7, Issues 5â6, May 2005, Pages 890-896
Journal: Microbes and Infection - Volume 7, Issues 5â6, May 2005, Pages 890-896
نویسندگان
Giada Rossini, Sara Pignatelli, Paola Dal Monte, Daria Camozzi, Tiziana Lazzarotto, Liliana Gabrielli, Maria R. Gatto, Maria P. Landini,