کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9296428 | 1596779 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of influenza vaccine on markers of inflammation and lipid profile
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کلمات کلیدی
hsCRPIL-6SAACDCAHAMCP-1LDL-CHDL-CAmerican Heart Association - انجمن قلب آمریکاinterleukin 6 - اینترلوکین 6cardiovascular disease - بیماری قلب و عروقیtumor necrosis factor α - تومور نکروز عامل αCVD - رسوب دهی شیمیایی بخار serum amyloid A - سرم آمیلوئید ATNF-α - فاکتور نکروز توموری آلفاhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالCenters for Disease Control and Prevention - مراکز کنترل و پیشگیری از بیماریmonocyte chemotactic protein 1 - پروتئین chemotactic monocyte 1high-sensitivity C-reactive protein - پروتئین واکنش پذیر با حساسیت بالا CC-reactive protein - پروتئین واکنشی سیCRP - پروتئین واکنشی سی یا سی. آر. پی Low-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کم
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Despite wide use of the influenza vaccine, relatively little is known about its effect on the measurement of inflammatory markers. Because inflammatory markers such as C-reactive protein (CRP) are increasingly being used in conjunction with lipids for the clinical assessment of cardiovascular disease and in epidemiologic studies, we evaluated the effect of influenza vaccination on markers of inflammation and plasma lipid concentrations. We drew blood from 22 healthy individuals 1 to 6 hours before they were given an influenza vaccination and 1, 3, and 7 days after the vaccination. Plasma CRP, interleukin (IL)-6, monocyte chemotactic protein 1, tumor necrosis factor α, IL-2 soluble receptor α, and serum amyloid A were measured, and differences in mean concentrations of absolute and normalized values on days 1, 3, and 7 were compared with mean baseline values. There was a significant increase in mean IL-6 (P < .01 absolute values, P < .001 normalized values) on day 1 after receiving the influenza vaccine. The mean increases in normalized high sensitivity CRP values were significant on day 1 (P < .01) and day 3 (P = .05), whereas the mean increase in normalized serum amyloid A was significant only on day 1 (P < .05). No significant changes were seen in mean concentrations of IL-2 soluble receptor α, monocyte chemotactic protein-1, or tumor necrosis factor-α. Of the lipids, significant decreases in mean concentrations of normalized triglyceride values were seen on days 1 (P < .05), 3 (P < .001), and 7 (P < .05) after vaccination. Our findings show that the influenza vaccination causes transient changes in select markers of inflammation and lipids. Consequently, clinical and epidemiologic interpretation of the biomarkers affected should take into account the possible effects of influenza vaccination.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 6, June 2005, Pages 323-327
Journal: Journal of Laboratory and Clinical Medicine - Volume 145, Issue 6, June 2005, Pages 323-327
نویسندگان
Michael Y. Tsai, Naomi Q. Hanson, Robert J. Straka, Tracy R. Hoke, Jose M. Ordovas, James M. Peacock, Valerie L. Arends, Donna K. Arnett,