کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9302208 | 1246276 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The influence of intracellular mTHPC concentration upon photobleaching dynamics
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The influence of intracellular mTHPC concentration upon photobleaching dynamics The influence of intracellular mTHPC concentration upon photobleaching dynamics](/preview/png/9302208.png)
چکیده انگلیسی
In this study, we report the effect of the local photosensitizer concentration upon the dynamics of the singlet oxygen-mediated photobleaching, within formalin-fixed keratinocytes. Although the cells were incubated at a single mTHPC dose, cell-to-cell variations in concentration were defined within the perinuclear region by differences in the initial amplitude of the laser-induced fluorescence emission, located around 652Â nm. At a fixed laser fluence-rate, it was found that the photobleaching, when plotted as a function of delivered light dose, proceeded more rapidly at higher drug concentration. The mTHPC spectral emission profile is shown to be approximately Lorentzian and remains unchanged as the photobleaching proceeds. This indicates that there is no perturbation of the detected signal due to the inner-filter effect.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Photodiagnosis and Photodynamic Therapy - Volume 2, Issue 3, September 2005, Pages 235-238
Journal: Photodiagnosis and Photodynamic Therapy - Volume 2, Issue 3, September 2005, Pages 235-238
نویسندگان
M. MPhil PhD, M.R. Stringer, J.E. Cruse-Sawyer, P.E. Dyer, S.B. Brown,