کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9302387 1246384 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DNA damages after SIM01 photodynamic treatment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
پیش نمایش صفحه اول مقاله
DNA damages after SIM01 photodynamic treatment
چکیده انگلیسی
Cell exposure to 20 J cm−2 after an incubation time of 2 h with 0, 0.25, 0.5, 2 or 4 μg mL−1 induced less than 25% of cell death but significant Tail Moment changes. If DNA damage intensity increased according to SIM01 doses under light exposure, importance of repair seemed to increase proportionally to PDT-induced damage. Positive controls consisted of doxorubicin-treated C6 cells this mutagen being known to induce genetic damage. Whatever the conditions used SIM01 appeared to be less deleterious than doxorubicin. As the comet assay can not give us the certitude that no mutation, photoadducts or oxidative damage had been developed under light exposure this point will have to be verified with another mutagenicity assay. SIM01 appears to be safe from a mutagenic point of view something of importance as tumors of small volume in patients with a long lifespan are at first indicated for PDT.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Photodiagnosis and Photodynamic Therapy - Volume 2, Issue 1, March 2005, Pages 25-33
نویسندگان
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