Mandibular pathologic fracture as a first sign of disseminated angiosarcoma: A case report and review of literatures

Angiosarcoma is a rare malignant tumor of vascular endothelium. The head and neck region are affected less than other parts of the body. Herein, we report a mandibular angiosarcoma manifested as a pathologic fracture of the mandible. Histological examination in conjuction with immunohistochemical evaluation of the primary intraoral biopsy revealed the lesion was an angiosarcoma. Workup of the patient for the metastasis revealed disseminated involvement of other parts of the body.