کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937330 1475226 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia
چکیده انگلیسی

Visuospatial learning and memory impairments are an early marker for age-related cognitive decline and Alzheimer’s disease. Similar to humans, aged dogs show visuospatial learning and memory deficits (Adams et al., 2000b). One hundred and nine beagle dogs ranging between 0.25 and 11.99 years were tested on a visuospatial delayed non-matching to position (DNMP) task to better characterize the progression of visuospatial deficits in the dog. Age predicted 48.2% of the variability in learning the DNMP, with dogs ranging from 1 to 11.99 years generally making more errors with increasing age. By contrast, puppies (<1 year) likely were showing developmental deficits, possibly due to an immature prefrontal cortex. Mild visuospatial deficits were detected by 6 years, which precedes the typical onset of amyloid-β (Aβ) accumulation in the dog brain by two years, and can serve as an early marker for cognitive decline in the dog. These findings suggest that (1) age-related changes in visuospatial function in the dog models that seen in humans, further validating the dog as a model for human aging and dementia; and (2) other mechanisms, such as oxidative stress, soluble Aβ oligomers or cholinergic deficits, are likely contributing to the early impairment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 86, Issue 2, September 2006, Pages 197–204
نویسندگان
, , , , , , ,