Computer-Aided Detection Applied to Breast MRI: Assessment of CAD-Generated Enhancement and Tumor Sizes in Breast Cancers Before and After Neoadjuvant Chemotherapy1

CAD may be helpful in assessing changes in MRI enhancement profiles of tumors following chemotherapy. However, CAD-assessed significant enhancement following chemotherapy can be falsely negative for residual malignancy, and CAD tumor sizes are less accurate than those measured by the radiologist in predicting size of residual malignancy. CAD may complement but should not replace the radiologist's assessment of tumors in this patient population.