2005 Dr. Gary J. Becker Young Investigator Award: Periprocedural Oral Administration of the Leflunomide Analogue FK778 Inhibits Neointima Formation in a Double-injury Rat Model of Restenosis

In the double-injury rat model presented, balloon-mediated proliferation of smooth muscle cells in the intima with consecutive intimal thickening was influenced by FK778 in a dose-dependent manner. However, long-term studies are needed to exclude a delay of vascular healing in this particular model.