کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416161 | 1292959 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kainate-activated currents in the ventral tegmental area of neonatal rats are modulated by interleukin-2
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کلمات کلیدی
IKAMesolimbicIL-2excitatory amino acid - آمینو اسید هیجان انگیزSchizophrenia - اسکیزوفرنی یا شیزوفرنیAutism - اوتیسم یا درخودماندگیInterleukin-2 - اینترلوکین-۲Neural–immune interactions - تعاملات ایمنی عصبیEndocrine and autonomic regulation - تنظیم غدد درون ریز و اتونومیکneurodevelopment - توسعه عصبیCNS - دستگاه عصبی مرکزیDopamine - دوپامینDevelopment - رشدNeurotoxicity - سمیت عصبیCytokine - سیتوکینcentral nervous system - سیستم عصبی مرکزیNeurogenesis - نوروژنز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Interleukin (IL)-2 is a potent modulator of neurotransmission and neuronal development in the mesolimbic and mesostriatal systems. It is also implicated in pathologies (including schizophrenia, Parkinson's disease, autism, cognitive disorders) that are linked with abnormalities in these systems. Since the kainate receptor plays an essential role in mesolimbic neuronal development and excitability, we examined the effects of physiologically relevant concentrations of IL-2 on kainate-activated current (IKA) in voltage-clamped neurons freshly isolated from the ventral tegmental area (VTA) of 3- to 14-day-old rats. IL-2 (0.01-10 ng/ml) alone had no effect on membrane conductance. When co-applied with kainate, IL-2 significantly decreased IKA. IL-2 (2 ng/ml) shifted the kainate concentration-response curve to the right in a parallel manner, significantly increasing the EC50 without changing the maximal IKA. IL-2 inhibition of IKA was voltage-dependent, being greater at negative potentials. IL-2 did not alter the reversal potential. These findings suggest that IL-2 potently modulates kainate receptors of developing mesolimbic neurons. We suggest that IL-2 plays a role in the excitability of developing neurons in the mesolimbic system. Inasmuch as increased IKA is associated with excitotoxicity, coupled with the present observation that IL-2 inhibits IKA, we suggest an adaptive role for IL-2 in limiting excitotoxicity in the developing brain. IL-2 might thus be required for normal cell development in the mesolimbic and mesostriatal systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1049, Issue 2, 12 July 2005, Pages 227-233
Journal: Brain Research - Volume 1049, Issue 2, 12 July 2005, Pages 227-233
نویسندگان
Jiang-Hong Ye, Steven S. Zalcman, Liang Tao,