کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416199 | 1614331 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers
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کلمات کلیدی
CBFdouble-stranded RNA-activated protein kinase (PKR)-like ER kinaseATF-4eIF2αUPRRyRMCAOTTCGFAPPVDFPBSMCASDS2,3,5-triphenyltetrazolium chloride - 2،3،5-trihenyltetrazolium chlorideC/EBP-homologous protein - C / EBP-homologous proteinCa2+ - Ca2 +DMSO - DMSODisorders of the nervous system - اختلالات سیستم عصبیmiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیIschemia - ایسکمیANOVA - تحلیل واریانس Analysis of varianceTerminal deoxynucleotidyl transferase-mediated dUTP nick end labeling - ترمینال deoxynucleotidyl transferase-mediated dUTP نام نهایی پایان نامهTUNEL - تونلCHOP - تکه کردنcerebral blood flow - جریان خون مغزیApoptosis - خزان یاختهایDantrolene - دندرولنDimethyl sulfoxide - دیمتیل سولفواکسیدsodium dodecyl sulfate - سدیم دودسیل سولفاتendoplasmic reticulum - شبکه آندوپلاسمی middle cerebral artery - شریان مغزی میانیeukaryotic initiation factor 2α - عامل آغاز کننده یوکاریوتی 2αactivating transcription factor-4 - فعال کردن عامل رونویسی 4Phosphate-buffered saline - محلول نمک فسفات با خاصیت بافریRat - موش صحراییUnfolded protein response - پاسخ پروتئین آشکارGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالPERK - پرکsham control - کنترل شامRyanodine receptor - گیرنده رایانودینCalcium ions - یون کلسیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers](/preview/png/9416199.png)
چکیده انگلیسی
The endoplasmic reticulum (ER) plays an important role in ischemic neuronal cell death. In order to determine the effect of dantrolene, a ryanodine receptor antagonist, on ER stress response and ischemic brain injury, we investigated changes in ER stress-related molecules, that is phosphorylated form of double-stranded RNA-activated protein kinase (PKR)-like ER kinase (p-PERK), phosphorylated form of eukaryotic initiation factor 2α (p-eIF2α), activating transcription factor-4 (ATF-4), and C/EBP-homologous protein (CHOP), as well as terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) in the peri-ischemic area and ischemic core region of rat brain after transient middle cerebral artery occlusion (MCAO). In contrast to the cases treated with vehicle, the infarct volume and TUNEL-positive cells were significantly reduced at 24 h of reperfusion by treatment with dantrolene. The immunoreactivities for p-PERK, p-eIF2α, ATF-4, and CHOP were increased at the ischemic peripheral region after MCAO, which were partially inhibited by dantrolene treatment. The present results suggest that dantrolene significantly decreased infarct volume and provided neuroprotective effect on rats after transient MCAO by reducing ER stress-mediated apoptotic signal pathway activation in the ischemic area.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1048, Issues 1â2, 28 June 2005, Pages 59-68
Journal: Brain Research - Volume 1048, Issues 1â2, 28 June 2005, Pages 59-68
نویسندگان
Feng Li, Takeshi Hayashi, Guang Jin, Kentaro Deguchi, Shoko Nagotani, Isao Nagano, Mikio Shoji, Pak H. Chan, Koji Abe,