کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9434411 1298150 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression profile of AMPA receptor subunit mRNA in single adult rat brain and spinal cord neurons in situ
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Expression profile of AMPA receptor subunit mRNA in single adult rat brain and spinal cord neurons in situ
چکیده انگلیسی
The differential expression of AMPA receptor subunit mRNA was analyzed in the adult rat brain and spinal cord using quantitative RT-PCR with laser capture microdissection. The expression of all four AMPA receptor subunits was demonstrable, with the mRNA expression level for GluR2 being the highest in all the brain areas and neuronal subsets examined. Both the absolute expression level of GluR2 mRNA and its expression relative to the other subunits were the lowest in motoneurons. The unique AMPA receptor expression profile of motoneurons may render them selectively vulnerable to AMPA receptor-mediated excitotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 52, Issue 3, July 2005, Pages 228-234
نویسندگان
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