کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
95339 160427 2015 10 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Regioisomeric and enantiomeric analyses of 24 designer cathinones and phenethylamines using ultra high performance liquid chromatography and capillary electrophoresis with added cyclodextrins
ترجمه فارسی عنوان
تجزیه و تحلیل Regioisomeric و enantiomeric از 24 cathinones طراح و phenethylamines با استفاده از کروماتوگرافی مایع با کارایی فوق العاده بالا و capillary electrophoresis با cyclodextrins اضافه
کلمات کلیدی
کروماتوگرافی مایع با کارایی بالا فوق العاده ؛ الکتروفورز مویرگی؛ مویرگی پوشیده شده پویا؛ Cathinones؛ Phenethylamines؛ Regioisomers؛ انانتیومرها
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی


• Regioisomeric and enantiomeric cathinones were determined by chiral CE.
• Ring-substituted phenethylamines and cathinones were separated by achiral UHPLC.
• UHPLC is less effective at the regioisomeric discrimination than chiral CE.

Designerphenethylamines (PEAs) and cathinones have been encountered worldwide. Complete characterization of these substances can be challenging due to their chirality and variably substituted phenyl rings. In this study, 24 PEAs and cathinones were analyzed by ultra high performance liquid chromatography with photo diode array detection (UHPLC-PDA) on a variety of stationary phases, and by capillary electrophoresis on a dynamically coated capillary with PDA detection (CE-PDA). In the UHPLC-PDA study, a BEH Phenyl column resolved 18 of the 24 regioisomers in 8 min, with good discrimination of the PEAs. In contrast, capillary zone electrophoresis (CZE) on a dynamically coated capillary partially or baseline resolved only 10 of the 24 regioisomers, but with improved discrimination of mono-substituted cathinones. A second series of CE-PDA experiments using 80 mM (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) in the run buffer resolved all 24 regioisomers and all but two sets of enantiomers within 18 min. Five illicit samples were successfully analyzed using the described methods.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International - Volume 254, September 2015, Pages 148–157
نویسندگان
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