کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9591355 1507019 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Putative structure and function of ORF3 in SARS coronavirus
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Putative structure and function of ORF3 in SARS coronavirus
چکیده انگلیسی
Based on molecular modeling techniques we constructed a rational 3D model of ORF3 in SARS coronavirus (SARS-CoV). Our studies suggest that the function of ORF3 could be involved in FAD/NAD binding according to its predicted structure and comparison with other structure neighbors. Furthermore, we identified three pairs of non-canonical N-H⋯π interactions in the structure of ORF3, which can make contributions to the stability of protein structure. These results provide important clues for better understanding of SARS-CoV ORF3 and trying new therapeutic strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure: THEOCHEM - Volume 715, Issues 1–3, 28 February 2005, Pages 55-58
نویسندگان
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