کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9601031 1410446 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fatal Radiation Myelopathy After High-dose Busulfan and Melphalan Chemotherapy and Radiotherapy for Ewing's Sarcoma: A Review of the Literature and Implications for Practice
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Fatal Radiation Myelopathy After High-dose Busulfan and Melphalan Chemotherapy and Radiotherapy for Ewing's Sarcoma: A Review of the Literature and Implications for Practice
چکیده انگلیسی
Radiation myelopathy is a rare, devastating, late effect of radiotherapy to the spinal cord. Spinal cord tolerance is currently accepted as about 50 Gy in 1.8-2 Gy fractions. However, the effect of chemotherapy on cord tolerance is unclear. This issue is important, given the increasing use of chemotherapy in combination with radiotherapy. We describe the case of a 17-year-old boy with a right apical paraspinal Ewing's tumour in the neck treated with induction chemotherapy, high-dose chemotherapy (busulfan and melphalan) with peripheral stem-cell rescue and, 4 months later, radiotherapy to the primary tumour site (cervical cord received 50 Gy in 30 fractions). After a latent period of 4 months, he developed a progressive, severe and ultimately fatal radiation myelopathy, which we suggest was due to a synergistic interaction between the high-dose chemotherapy and the radiotherapy. The use of such chemotherapy regimens in Ewing's tumours should be carefully considered, particularly when radiotherapy encompassing the spinal cord is an essential component of management.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Oncology - Volume 17, Issue 5, August 2005, Pages 385-390
نویسندگان
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