کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9605764 | 44156 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spectral properties of stilbazolium merocyanines - potential sensitizers in photodynamic therapy and diagnosis
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کلمات کلیدی
PVALIOASLaser-induced optoacoustic spectroscopyMerocyaninePDDBPbPhytohemagglutininISCPDTPHATrpFITCPBSBCPAnnexin-V - آنیونین VFluorescence emission - انتشار فلورسانسBromophenol Blue - بروموفنول آبیBromocresol purple - بروموکرسول بنفشFluorescence excitation - تحریک فلورسانسTryptophan - تریپتوفانPhotodynamic diagnosis - تشخیص فوتودینامیکTyr - تیرPhotodynamic therapy - درمان فتودینامیکIntersystem crossing - عبور از داخل سیستمThermal deactivation - غیرفعال کردن حرارتیPhosphate buffered saline - فسفات بافر شورFluorescein - فلورسئینPropidium iodide - پروتئین یدیدpolyvinyl alcohol - پلی ونیل الکل
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The efficiency of triplet states generation of the dyes incorporated into stimulated cells has been evaluated using time-resolved photothermal spectroscopy. As follows from the photographs of stained cancerous cells taken by means fluorescence microscope, merocyanines are located predominantly in cell membranes. The spectral properties of the dye-sensitizes in solutions and in the cells can differ therefore the selection of proper sensitizers for medical applications made on the ground of the investigation of dye molecules in simple artificial model systems is only preliminary. The selected dyes have to be further investigated after introducing them into resting and PHA-stimulated lymphocytes. It has been shown that the dyes exhibiting high yields of triplet state generation in the stimulated cells usually are also efficient sensitizers of photodynamic reactions. The exceptions are the dyes undergoing fast photobleaching in the cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 169, Issue 2, 15 January 2005, Pages 159-168
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 169, Issue 2, 15 January 2005, Pages 159-168
نویسندگان
Ewa StaÅkowiak, Alina Dudkowiak, Krzysztof Wiktorowicz, Justyna Cofta, Danuta Fra̧ckowiak,