کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9616747 | 48920 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipase-catalyzed regioselective synthesis of lipophilic inosine ester derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
کاتالیزور
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چکیده انگلیسی
Enzymatic synthesis of fatty acid inosine esters was performed by the immobilized lipase from Mucor miehei (Lipozyme®)-catalyzed transesterification reaction of inosine and vinyl fatty acid esters (from vinyl caprylate to vinyl stearate) in acetone. Inosine was regioselectivly acylated at the primary hydroxyl groups and inosine derivatives with long chain acyl group were prepared in good yields. Reaction conditions including enzyme resources and solvents for the esterification were examined. The obtained 5â²-O-acyl derivatives are more lipophilic than the parent inosine and thus suitable for potentially pharmaceutical application.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 35, Issues 1â3, 1 August 2005, Pages 14-18
Journal: Journal of Molecular Catalysis B: Enzymatic - Volume 35, Issues 1â3, 1 August 2005, Pages 14-18
نویسندگان
Na Wang, Qi Wu, Wei Bo Wu, Jing Quan, Xian Fu Lin,