کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9646324 548018 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
چکیده انگلیسی
Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases = 405, controls = 401) and second-set analysis (cases = 503, controls = 440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 78, Issues 2–3, 15 October 2005, Pages 127-130
نویسندگان
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