کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9675515 | 1454099 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Spontaneous incorporation of β-amyloid peptide into neutral liposomes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
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چکیده انگلیسی
The β-amyloid peptide (Aβ) is the primary constituent of senile plaques, a defining feature of Alzheimer's disease. Aβ presumably exerts its neurotoxic action through an interaction with neuronal membranes. We have studied the effect of neutral liposomes (average diameter â 200 nm) on the kinetics of Aβ fibrillogenesis, and on the binding of fibrillar peptide to the dye Congo Red. Our results indicate that neutral liposomes increase the time of Aβ autoaggregation in a concentration-dependent manner. This delay is mainly due a reduction of the nucleation constant. In addition, binding studies reveal that the amount of fibrillar Aβ, as well as the concentration of binding sites, decreases in the presence of liposomes. Our findings suggest that Aβ partially penetrates the lipid membrane.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volumes 270â271, 1 December 2005, Pages 13-17
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volumes 270â271, 1 December 2005, Pages 13-17
نویسندگان
Raimon Sabaté, Montserrat Gallardo, Joan Estelrich,