کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9676087 | 1454114 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of sol-gel silica materials providing a slow release of biphosphonate
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to synthesize silica materials that would provide a slow release of biphosphonate. The biphosphonate used in this work, etidronate, is a small water-soluble molecule that can be used to inhibit bone resorption in the body, since calcium ions can be complexed to the biphosphonate through a bidentate bond. This kind of silica material could therefore serve as active filler in polymer-based implants. The biphosphonate was incorporated into the silica during the spray-drying step, and the silica could provide a slow release on the month time-scale. The release process is suggested to be controlled by both erosion and diffusion processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 254, Issues 1â3, 10 March 2005, Pages 69-74
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 254, Issues 1â3, 10 March 2005, Pages 69-74
نویسندگان
Teresa Czuryszkiewicz, Sami Areva, Mari Honkanen, Mika Lindén,