کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9743879 | 1491201 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sequential spectrophotometric determination of paracetamol and p-aminophenol with 2,2â²-(1,4-phenylenedivinylene) bis-8-hydroxyquinoline as a novel coupling reagent after microwave assisted hydrolysis
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A new method to determine paracetamol and p-aminophenol in pharmaceutical products is presented. The purpose of this work is to introduce 2,2â²-(1,4-phenylenedivinylene) bis-8-hydroxyquinoline (PBHQ) as a novel coupling agent. This developed method is based on the microwave assisted alkaline hydrolysis of paracetamol to p-aminophenol, which reacts in mildly alkaline medium with 2,2-(1,4-phenylenedivinylene)bis-8-hydroxyquinoline (PBHQ) as a novel coupling reagent. The formed product shows maximum absorbance at 650 nm with molar absorptivity = 3.4 Ã 104 l molâ1 cmâ1 and the method was linear in the 0.44-5.5 mg lâ1 concentration range. The detection limit value was found to be 0.09 μg mlâ1. The stoichiometric composition of the dye is 2:1 (PAP:PBHQ). The effect of concentration of reactants and temperature on the coupling reaction was investigated. The proposed method is successfully adopted for the determination of paracetamol and p-aminophenol in various pharmaceutical preparations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytica Chimica Acta - Volume 535, Issues 1â2, 11 April 2005, Pages 177-182
Journal: Analytica Chimica Acta - Volume 535, Issues 1â2, 11 April 2005, Pages 177-182
نویسندگان
Hayati Filik, Mustafa Hayvali, Emine Kilic,