کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9749314 1493806 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Capillary zone electrophoresis separation of enantiomers of lisuride
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Capillary zone electrophoresis separation of enantiomers of lisuride
چکیده انگلیسی
Lisuride is an ergot alkaloid derivative with dopaminergic activity. It is used for treatment of Parkinsonism and some other diseases associated with high level of prolactine. Lisuride is a chiral compound derived from natural ergot alkaloids. A new capillary zone electrophoresis (CZE) method capable of separating the enantiomers of lisuride was developed. Using the optimized conditions (acidic electrolyte with the addition of gamma-cyclodextrin (γ-CD)) as low as 0.02% of undesirable l-lisuride can be detected. Selected method characteristics, i.e., linearity (0-20 mg/l), precision (2.0% at 5 mg/l), and accuracy (101 ± 4% at 5 mg/l) were evaluated. The optimized method was applied for the analysis of real batches of Lisuride hydrogenmaleate and Lisuride base manufactured by IVAX Pharmaceuticals. It was found that they contain less than 0.02% of undesirable l-enantiomer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1066, Issues 1–2, 25 February 2005, Pages 255-258
نویسندگان
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