کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9754449 1494678 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chiral separation of tamsulosin by capillary electrophoresis
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Chiral separation of tamsulosin by capillary electrophoresis
چکیده انگلیسی
Enantiomers of (±) 5-[2 (R,S)-{[2-(o-ethoxyphenoxy) ethyl] amino} propyl]-2-methoxy-benzenesulfonamide (tamsulosin, drug frequently used in the treatment of prostate diseases) were separated by capillary electrophoresis (CE). An acidic background electrolyte (BGE) with sulfated-β-cyclodextrin (S-β-CD) was used to create a chiral separation environment. Baseline separation of the isomers was achieved during 5 min using cathodic electro-osmotic flow (EOF) (countercurrent mode). The quantification limits were 5.3 × 10−6 mol l−1 for R-isomer and 5.7 × 10−6 mol l−1 for S-isomer. The R.S.D. values of peak area were 0.54% for R-isomer and 0.75% for S-isomer. The results achieved enable determination of 0.5% of optical impurity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 39, Issues 3–4, 15 September 2005, Pages 691-696
نویسندگان
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