Voltammetric study of interaction between polymers (PEI and TMO) and pDNA on a hanging mercury drop electrode

Electrochemical DNA biosensors can become a powerful tool for the investigation of potent changes on the plasmid DNA structure caused by polymers used as non-viral vectors in gene delivery. Trimethylated chitosan oligomer (TMO) and polyethylenimine (PEI), offering biocompatibility, low immunogenicity and minimal cytotoxicity, are being studied as model non-viral carriers. The information obtained is intended to serve as a basis for developing a new analytical system for the study of the effect of any physically or chemically synthesized polymer on DNA structure.