کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9774596 | 1509089 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regiochemical functionalization of a nanoscale cage-like structure: Robust core-shell nanostructures crafted as vessels for selective uptake and release of small and large guests
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
بیومتریال
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regiochemical functionalization of a nanoscale cage-like structure: Robust core-shell nanostructures crafted as vessels for selective uptake and release of small and large guests Regiochemical functionalization of a nanoscale cage-like structure: Robust core-shell nanostructures crafted as vessels for selective uptake and release of small and large guests](/preview/png/9774596.png)
چکیده انگلیسی
As synthetic methods evolve toward the preparation of increasingly complex nanostructured materials inspired from biological nano-objects, the ability to tailor the three-dimensional architecture and the placement of functional groups at well-defined positions within those frameworks is advancing. In this report, we demonstrate the ability to functionalize selectively internal and external sites (regiochemically) within polymer nanocages, to advance their development as synthetic analogs of viral capsids. Nanocages, possessing carbonyl groups on their internal surfaces and acrylic acid residues throughout their structure were prepared and functionalized, through either Schiff-base chemistry, to attach covalently phosphatidylethanolamine-based lipids within the nanocage, or carbodiimide-mediated coupling, to attach covalently the lipids throughout the shell. The resulting nanostructures were altered by the insertion of molecules within and on the structure, including, for the Schiff base functionalized nanostructure, an enhanced response to pH and increased uptake of hydrophobic guests. Additionally, the use of phosphatidylethanolamine lipids labeled with 7-nitrobenz-2-oxa-1,3-diazole (NBD) allowed for determination of the environmental polarities of the lipid domains within the lipid-nanocage constructs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 109, Issues 1â3, 5 December 2005, Pages 189-202
Journal: Journal of Controlled Release - Volume 109, Issues 1â3, 5 December 2005, Pages 189-202
نویسندگان
Jeffrey L. Turner, Zhiyun Chen, Karen L. Wooley,