کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
98734 160887 2016 14 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Validating multiplexes for use in conjunction with modern interpretation strategies
ترجمه فارسی عنوان
اعتبار multiplexes برای استفاده در ارتباط با استراتژی های تفسیر مدرن
کلمات کلیدی
تفسیر DNA پزشکی قانونی . GlobalFiler؛ تفسیر DNA مداوم. STRmix؛ مدلسازی؛ مخلوط DNA
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی

In response to requests from the forensic community, commercial companies are generating larger, more sensitive, and more discriminating STR multiplexes. These multiplexes are now applied to a wider range of samples including complex multi-person mixtures. In parallel there is an overdue reappraisal of profile interpretation methodology. Aspects of this reappraisal include1.The need for a quantitative understanding of allele and stutter peak heights and their variability,2.An interest in reassessing the utility of smaller peaks below the often used analytical threshold,3.A need to understand not just the occurrence of peak drop-in but also the height distribution of such peaks, and4.A need to understand the limitations of the multiplex-interpretation strategy pair implemented.In this work we present a full scheme for validation of a new multiplex that is suitable for informing modern interpretation practice. We predominantly use GlobalFiler™ as an example multiplex but we suggest that the aspects investigated here are fundamental to introducing any multiplex in the modern interpretation environment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International: Genetics - Volume 20, January 2016, Pages 6–19
نویسندگان
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