کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9882346 | 1536555 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Redox control of catalytic activities of membrane-associated protein tyrosine kinases
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کلمات کلیدی
SRCLCKCysteine residue - باقی مانده سستیونRET - حقActivation loop - حلقه فعالTyrosine phosphorylation - فسفوریلاسیون تروفوزینMembrane raft - قایق غارProtein tyrosine kinase - پروتئین تیروزین کینازredox control - کنترل بازتوکسReactive oxygen species - گونههای فعال اکسیژنglycosylphosphatidylinositol anchor - گچسالی فسفاتیدیلینیستول لنگر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Redox control of catalytic activities of membrane-associated protein tyrosine kinases Redox control of catalytic activities of membrane-associated protein tyrosine kinases](/preview/png/9882346.png)
چکیده انگلیسی
Protein tyrosine kinases (PTKs) play key roles in starting the signal transduction network for cellular development and functions. A number of both receptor-type and non-receptor-type PTKs, which are normally at a resting state, are initially activated in association with functions of the cell membrane and membrane rafts. Results of recent studies have suggested that these membrane-associated mechanisms for activation of PTKs consist of the two steps that are under redox control. The first step is activation of cell surface receptors through chemical crosslinkage or aggregation of receptors and membrane rafts, which leads to production of reactive oxygen species (ROS) as second messengers of intracellular signal transduction. The second step involves chemical modification of PTKs at the highly conserved cysteine in the MXXCW motif as a global switch for starting the tyrosine phosphorylation-dependent local switch for activation of the catalytic activity of the enzyme.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 434, Issue 1, 1 February 2005, Pages 3-10
Journal: Archives of Biochemistry and Biophysics - Volume 434, Issue 1, 1 February 2005, Pages 3-10
نویسندگان
Izumi Nakashima, Kozue Takeda, Yoshiyuki Kawamoto, Yusuke Okuno, Masashi Kato, Haruhiko Suzuki,