کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9888118 | 1538770 | 2005 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid)
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کلمات کلیدی
ALDHURAT1MEOSALDH2ADHaldehyde dehydrogenase - آلدئید دهیدروژنازMitochondrial aldehyde dehydrogenase - آلدئید دهیدروژناز میتوکندریالEthanol - اتانولUric acid - اسید اوریکAlcohol - الکلAlcohol dehydrogenase - الکل دهیدروژنازUrate transporter 1 - حمل کننده اورات 1Xanthine - زانتیmicrosomal ethanol-oxidizing system - سیستم اکسید کننده اتانول میکروسیمالinorganic phosphate - فسفات معدنیhypoxanthine - هیپوکسانتینPurine bases - پایگاه های پورین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid) Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid)](/preview/png/9888118.png)
چکیده انگلیسی
There are many factors that contribute to hyperuricemia, including obesity, insulin resistance, alcohol consumption, diuretic use, hypertension, renal insufficiency, genetic makeup, etc. Of these, alcohol (ethanol) is the most important. Ethanol enhances adenine nucleotide degradation and increases lactic acid level in blood, leading to hyperuricemia. In beer, purines also contribute to an increase in plasma uric acid. Although rare, dehydration and ketoacidosis (due to ethanol ingestion) are associated with the ethanol-induced increase in serum uric acid levels. Ethanol also increases the plasma concentrations and urinary excretion of hypoxanthine and xanthine via the acceleration of adenine nucleotide degradation and a possible weak inhibition of xanthine dehydrogenase activity. Since many factors such as the ALDH2*1 gene and ADH2*2 gene, daily drinking habits, exercise, and dehydration enhance the increase in plasma concentration of uric acid induced by ethanol, it is important to pay attention to these factors, as well as ingested ethanol volume, type of alcoholic beverage, and the administration of anti-hyperuricemic agents, to prevent and treat ethanol-induced hyperuricemia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinica Chimica Acta - Volume 356, Issues 1â2, June 2005, Pages 35-57
Journal: Clinica Chimica Acta - Volume 356, Issues 1â2, June 2005, Pages 35-57
نویسندگان
Tetsuya Yamamoto, Yuji Moriwaki, Sumio Takahashi,