کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9890037 1539998 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular mechanisms of TNF-α-induced apoptosis in aging human T cell subsets
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Molecular mechanisms of TNF-α-induced apoptosis in aging human T cell subsets
چکیده انگلیسی
TNF-α, a pro-inflammatory cytokine, exerts its biological activity by signaling via its two receptors, TNFR-1 and TNFR-2 and by activating NF-κB. NF-κB is essential for survival of many cell types; however, TNF-α also induces cell death. During human aging TNF-α production and TNF-α-induced apoptosis are increased. In this brief review, we will discuss the TNF-α-mediated signaling and various molecular mechanisms underlying increased apoptosis in T cell subsets in aged humans with a special reference to alterations in transcription factor NF-κB and Fas-associated death domain (FADD).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 37, Issue 5, May 2005, Pages 1034-1042
نویسندگان
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