کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9890117 1540002 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microglia: phagocyte and glia cell
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Microglia: phagocyte and glia cell
چکیده انگلیسی
Microglia are the resident immune cells of the brain, and are located within the brain parenchyme behind the blood-brain barrier. They originate from mesodermal hemapoietic precursors and are slowly turned over and replenished by proliferation in the adult central nervous system. In the healthy brain resting, ramified microglia function as supportive glia cells, and their activation status is regulated by neurons through soluble mediators and cell-cell contact. However, in response to brain pathology microglia become activated: acquisition of innate immune cell functions render microglia competent to react towards brain injury through tissue repair or induction of immune responses. In certain pathological conditions, however, microglia activation may sustain a chronic inflammation of the brain, leading to neuronal dysfunction and cell death. This might be mediated by the microglial release of extracellular toxic reactive oxygen and nitrogen species. Nevertheless, in the future microglia may potentially be harnessed for therapeutical purposes.Cell facts
- Resident immune cell of the brain.
- Constitute approximately 20% of the total glia cell population.
- Originate from mesodermal precursor cells of hemapoietic lineage.
- Traditionally divided into resting (ramified) and activated (ameboid) microglia.
- Resident microglia are slowly turned over and replaced by proliferation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 37, Issue 1, January 2005, Pages 17-21
نویسندگان
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