کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
98904 160911 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
FamLink – A user friendly software for linkage calculations in family genetics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
FamLink – A user friendly software for linkage calculations in family genetics
چکیده انگلیسی

The present number of STR loci adopted in relationship testing is chiefly limited to unlinked markers, in most cases residing on different chromosomes. In order to solve more complex cases of relatedness, e.g. deficient paternities and disputed sibships, the number of core loci can be extended. The inclusion of multiple loci on the same chromosome will, however, increase the risk of possible linkage between markers. We present a new software, FamLink, freely available from http://www.FamLink.se, that can perform statistical calculations based on pedigree structures and account for linkage between pairs of markers. In addition, FamLink can simulate genotype data in order to study the effect of accounting for linkage or not. We demonstrate the importance of taking linkage properly into account using examples and real cases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Forensic Science International: Genetics - Volume 6, Issue 5, September 2012, Pages 616–620
نویسندگان
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