کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9893101 | 1541303 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Telmisartan inhibits expression of a receptor for advanced glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension
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کلمات کلیدی
sRAGERAGEAGEsVCAM-1RASRT-PCRICAM-1receptor for AGEsACENACHDLARBs - ARB هاECs - EC هاhigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاN-acetylcysteine - N-استیل سیستئینAngiotensin-converting enzyme - آنژیوتانسین تبدیل آنزیمAngiotensin II - آنژیوتانسین دوELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاAng II - دومEndothelial cells - سلولهای اندوتلیالRenin–angiotensin system - سیستم رنین-آنژیوتانسینBlood pressure - فشارخونAdvanced glycation end products - محصولات نهایی پیشرفته گلیساسیونintracellular adhesion molecule-1 - مولکول چسبندگی داخل سلولی -1vascular cell adhesion molecule-1 - مولکول چسبندگی سلولی عروقی-1reverse transcription-polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسAT1 receptor - گیرنده AT1ANG II type 1 receptor - گیرنده دوم نوع 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Telmisartan inhibits expression of a receptor for advanced glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension Telmisartan inhibits expression of a receptor for advanced glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension](/preview/png/9893101.png)
چکیده انگلیسی
There is a growing body of evidence that the advanced glycation end product (AGE)-their receptor (RAGE) system plays a central role in the pathogenesis of diabetic vascular complication. The renin-angiotensin system (RAS) contributes to the development and progression of diabetic angiopathy as well. However, the cross-talk between the AGE-RAGE system and the RAS is not fully understood. In this study, we examined the role of angiotensin II (Ang II) type 1 receptor system for RAGE expression in cultured endothelial cells (ECs) and in patients with essential hypertension. Ang II up-regulated RAGE mRNA levels of microvascular ECs and subsequently increased the soluble form of RAGE (sRAGE) expression in the medium of ECs, both of which were completely blocked by telmisartan, a commercially available Ang II type 1 receptor antagonist. Furthermore, telmisartan was found to decrease serum levels of sRAGE in patients with essential hypertension. These results demonstrate that sRAGE is released from the cell surface of Ang-II-exposed ECs. Our present study indicates that a cross-talk exists between the AGE-RAGE system and the RAS and suggests that serum levels of sRAGE may reflect endothelial RAGE expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microvascular Research - Volume 70, Issue 3, November 2005, Pages 137-141
Journal: Microvascular Research - Volume 70, Issue 3, November 2005, Pages 137-141
نویسندگان
Kazuo Nakamura, Sho-ichi Yamagishi, Yayoi Nakamura, Katsuhiko Takenaka, Takanori Matsui, Yuko Jinnouchi, Tsutomu Imaizumi,