کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9901460 | 1545422 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The human epidermis models EpiSkin®, SkinEthic® and EpiDerm®: An evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport
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کلمات کلیدی
SPRRHPTLCmRNASLSUVATLCSodium laurylsulfate3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyl tetrazolium bromidestratum granulosum - granulosum stratumMTT - MTTO/W - O / Wmessenger RNA - RNA messengerW/O/W - W / O / WReconstructed human epidermis - اپی ادیس انسانی بازسازی شدهinterleukin - اینترلوکینDrug delivery - تحویل(رهایش) داروLipid composition - ترکیب لیپیدlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Stratum corneum - لایه شاخی، استراتوم کورنئومBiochemical markers - نشانگرهای بیوشیمیاییoil/water - نفت / آبSkin - پوستthin layer chromatography - کروماتوگرافی لایه نازکhigh performance thin layer chromatography - کروماتوگرافی نازک با عملکرد بالا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The human epidermis models EpiSkin®, SkinEthic® and EpiDerm®: An evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport The human epidermis models EpiSkin®, SkinEthic® and EpiDerm®: An evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport](/preview/png/9901460.png)
چکیده انگلیسی
The commercially available reconstructed human epidermis models EpiSkin®, SkinEthic® and EpiDerm® demonstrate reasonable similarities to the native human tissue in terms of morphology, lipid composition and biochemical markers. These models have been identified as useful tools for the testing of phototoxicity, corrosivity and irritancy, and test protocols have been developed for such applications. For acceptance of these tests by the authorities, prevalidation or validation studies are currently in progress. Furthermore, first results also indicate their suitability for transport experiments of drugs and other xenobiotics across skin. Still, however, the barrier function of these reconstructed human epidermis models appears to be much less developed compared to native skin. Further adaptation of the models to the human epidermis, especially concerning the barrier function, therefore remains an important challenge in this area of research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 60, Issue 2, July 2005, Pages 167-178
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 60, Issue 2, July 2005, Pages 167-178
نویسندگان
Frank Netzlaff, C.-M. Lehr, P.W. Wertz, U.F. Schaefer,