کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918551 | 1557548 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Drug release from complexes with a series of poly(carboxyalkyl methacrylates), a new class of weak polyelectrolytes
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
Carboxyalkyl methacrylates, a new class of non-cross-linked, hydrophobic weak polyelectrolytes, were synthesized, and then bound to cationic drugs (propranolol·HCl, diltiazem·HCl and verapamil·HCl) to form water-insoluble complexes that release the bound drug only in ionic media (pH 7.4). Compressed tablets were prepared from these cation exchange polyelectrolytes. Release profiles followed zero order kinetics (n > 0.90; n is the release exponent). As the hydrophobicity of the polyelectrolytes increased, the rate of release decreased and deviated from linearity (n = 0.7). Both the ionic strength of the medium as well as the solubility of the drug affected the rate of release. In acidic media (pH 1.2) a burst of drug was released but the release was halted by a layer of non-ionized polymer precipitated on the surface of the tablets. The results indicate that it is possible to “tailor-make” the release kinetics by using a polyelectrolyte from the series with the suitable hydrophobicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 305, Issues 1â2, 23 November 2005, Pages 52-60
Journal: International Journal of Pharmaceutics - Volume 305, Issues 1â2, 23 November 2005, Pages 52-60
نویسندگان
Jose M. Cornejo-Bravo, Maria E. Flores-Guillen, Eder Lugo-Medina, Angel Licea-Claverie,