کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9918554 1557548 2005 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of action of novel skin penetration enhancers: Phospholipid versus skin lipid liposomes
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Mechanisms of action of novel skin penetration enhancers: Phospholipid versus skin lipid liposomes
چکیده انگلیسی
Employing thermal analysis, we investigated the mechanism of action of novel enhancers and probed phospholipid (PL) versus stratum corneum lipid (SCL) liposomes as model membranes. The enhancers included octyl salicylate (OS), padimate O (PADO) and 2-(1-nonyl)-1,3-dioxolane (ND). The negative controls were the empty liposomes. Positive controls employed dimethylsulfoxide (DMSO) and Azone™ (AZ). For PL liposomes, DMSO sharpened the transitions. AZ abolished the pre-transition, broadened the main transition and linearly reduced its transition temperature (Tm). OS or PADO reduced Tm and size of pre-transition, broadened the main transition and decreased its Tm (non-linearly). ND abolished the pre-transition but increased Tm of the main endotherm, suggesting retardation rather than enhancement. The results of SCL correlated with PL liposomes except for ND. In SCL liposomes, ND reduced Tm and broadened the peaks indicating lipid disruption, which indicated its enhancing effects. In conclusion, OS, PADO and ND can enhance drugs by disrupting intercellular lipid domain but they differ from AZ in terms of the relationship between efficacy and concentration. Although PL liposomes are simple model membranes with sharp transitions which give detailed information about the effects of enhancers, they can provide misleading results. Simultaneous use of other models like SCL liposomes is recommended.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 305, Issues 1–2, 23 November 2005, Pages 90-104
نویسندگان
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