کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918670 | 1557552 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
Double-wall microspheres (DWMS), comprising distinct polymer core and shell phases, are useful and interesting for controlled-release drug delivery. In particular, the presence of a surface-eroding polymer core may be expected to limit water penetration and, therefore, delay degradation of the core phase and drug release. In this study, solid microspheres and DWMS were fabricated using a surface-eroding polymer (poly[1,6-bis(p-carboxyphenoxy)hexane]; PCPH) and a bulk-eroding polymer (poly(d,l-lactide-co-glycolide); PLG). Erosion of the particles was observed by optical and electron microscopy, while polymer degradation was followed by gel permeation chromatography, during incubation in buffer at 37 °C. Degradation and erosion were very different depending on which polymer formed the particle shell. Nevertheless, the relatively thin (â¼5 μm) PCPH shells could not prevent water penetration, and the PLG cores completely eroded by 6 weeks of incubation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 301, Issues 1â2, 14 September 2005, Pages 294-303
Journal: International Journal of Pharmaceutics - Volume 301, Issues 1â2, 14 September 2005, Pages 294-303
نویسندگان
Emily J. Pollauf, Cory Berkland, Kyekyoon (Kevin) Kim, Daniel W. Pack,