کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918675 | 1557553 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ultra-deformable liposomes containing bleomycin: In vitro stability and toxicity on human cutaneous keratinocyte cell lines
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
In vitro data revealed that the LD50 of bleomycin encapsulated in Bleosome⢠was approximately three-fold higher than free bleomycin solution for SCC cells, and nearly 30 times higher for NEB-1 cells. However, Bleosome⢠containing 30 μg/ml of active bleomycin killed more than twice as many SCC cells than NEB-1 cells. At that concentration, the potency of liposomal bleomycin on causing cell death of SCC cells was found to be similar to that of free bleomycin solution. This effect was not seen on NEB-1 cells. It seems that SCC cells were particularly susceptible to Bleosome⢠containing high levels of bleomycin. Results from these experiments promote the development of a novel product for the topical treatment of skin cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 300, Issues 1â2, 26 August 2005, Pages 4-12
Journal: International Journal of Pharmaceutics - Volume 300, Issues 1â2, 26 August 2005, Pages 4-12
نویسندگان
Kent G. Lau, Yoshiyuki Hattori, Sunil Chopra, Edel A. O'Toole, Alan Storey, Tsuneji Nagai, Yoshie Maitani,