کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918721 | 1557555 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cholesterol-bile salt vesicles as potential delivery vehicles for drug and vaccine delivery
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cholesterol-bile salt vesicles as potential delivery vehicles for drug and vaccine delivery Cholesterol-bile salt vesicles as potential delivery vehicles for drug and vaccine delivery](/preview/png/9918721.png)
چکیده انگلیسی
The aim of this study was to further investigate the interactions between cholesterol (CH) and mixed bile salts (BS) (sodium cholate and sodium deoxycholate) and their suitability for drug and vaccine delivery. Insulin was used as a model protein to assess the ability of CH:BS vesicles to entrap a therapeutically relevant macromolecule. The association of protein (FITC-insulin) with the CH:BS structure was confirmed with fluorescence microscopy, and the overall morphology of the vesicles was examined with atomic force microscopy (AFM). Results demonstrate that the nature of the vesicles formed between CH and BS is dependent not only on the concentration of BS but also on the increasing CH concentration leading to CH crystal formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 298, Issue 2, 25 July 2005, Pages 339-343
Journal: International Journal of Pharmaceutics - Volume 298, Issue 2, 25 July 2005, Pages 339-343
نویسندگان
C. Martin, J. Thongborisute, H. Takeuchi, H. Yamamoto, Y. Kawashima, H.O. Alpar,