کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918813 | 1557559 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intercalation of the radical scavenger ferulic acid in hydrotalcite-like anionic clays
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Intercalation of the radical scavenger ferulic acid in hydrotalcite-like anionic clays Intercalation of the radical scavenger ferulic acid in hydrotalcite-like anionic clays](/preview/png/9918813.png)
چکیده انگلیسی
Hydrotalcite is a biocompatible lamellar anionic clay formed by double hydroxide layers with a metal cation coordinating four OH groups. The different layers are held together by anionic hosts that can be replaced by a simple ion-exchange process. The synthetic Mg-Al-hydrotalcite was used to intercalate ferulic acid, a compound that shows antioxidant properties due to its free radical scavenger capacity. Analysis of the intercalated compound showed a good intercalation percentage (35.53%) accompanied by an increase of the interlayer space from 7.8Â Ã
(chloride form) to 17.1Â Ã
due to the presence of the ferulate. The intercalation product was stable in water, did not show any significant degradation after UV-irradiation, had a higher capacity of UV absorption in comparison to both the pure ferulic acid and ferulic acid-hydrotalcite chloride physical mixture. The intercalated compound was formulated in a siliconic cream and the ferulate in vitro release profiles determined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 295, Issues 1â2, 13 May 2005, Pages 47-55
Journal: International Journal of Pharmaceutics - Volume 295, Issues 1â2, 13 May 2005, Pages 47-55
نویسندگان
C. Rossi, A. Schoubben, M. Ricci, L. Perioli, V. Ambrogi, L. Latterini, G.G. Aloisi, A. Rossi,