In vitro characterization of some biopharmaceutical properties of praziquantel

Results showed that praziquantel was absorbed by passive diffusion. The apparent permeability constant value was 4.4 × 10−5 cm/s. Binding was not influenced by the addition of highly bound drugs. Dissolution from a tablet formulation showed that the rate of praziquantel was dependent on the components of the media. Although the simulated media could explain the influence of the lipids on praziquantel absorption, they were not able to forecast the influence of carbohydrates. Further refinements are required to explain the in vivo data.