کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918834 | 1557559 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of nanoprecipitation on the physicochemical properties of low molecular weight poly(l-lactic acid) nanoparticles loaded with salbutamol sulphate and beclomethasone dipropionate
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of nanoprecipitation on the physicochemical properties of low molecular weight poly(l-lactic acid) nanoparticles loaded with salbutamol sulphate and beclomethasone dipropionate Effect of nanoprecipitation on the physicochemical properties of low molecular weight poly(l-lactic acid) nanoparticles loaded with salbutamol sulphate and beclomethasone dipropionate](/preview/png/9918834.png)
چکیده انگلیسی
A modified nanoprecipitation (interfacial polymer deposition following solvent displacement) method was used to produce nanoparticles from low molecular weight poly(l-lactic acid). Model drugs, either salbutamol sulphate or beclomethasone dipropionate, were encapsulated in the particles. The influence of the preparation method on the physicochemical state of the polymer and the drugs as well as on the drug-polymer interactions were studied by electron microscopy, X-ray diffractometry, thermal analysis and infrared spectroscopy. Nanoprecipitation lowered the crystallinity of the PLA polymer. The crystallinity of the polymer was higher in the particles containing salbutamol sulphate then those containing beclomethasone dipropionate. The crystal form of beclomethasone dipropionate was changed from an anhydrate to a monohydrate as a result of nanoprecipitation. Although changes in the crystallinity of the polymer and the model drugs were seen, no clear interactions between the polymer and the drug were detected.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 295, Issues 1â2, 13 May 2005, Pages 269-281
Journal: International Journal of Pharmaceutics - Volume 295, Issues 1â2, 13 May 2005, Pages 269-281
نویسندگان
S. Hyvönen, L. Peltonen, M. Karjalainen, J. Hirvonen,