کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918867 | 1557561 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glycerin fatty acid esters as a new lubricant of tablets
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Glycerin fatty acid esters as a new lubricant of tablets Glycerin fatty acid esters as a new lubricant of tablets](/preview/png/9918867.png)
چکیده انگلیسی
Lubrication properties were compared among glycerin fatty acid esters (Poem TR-FB® and Poem TR-HB®), magnesium stearate (Mg-St), and a sucrose fatty acid ester (RYOTO SUGAR ESTER S-370F®: SSE). Granules containing 50% acetaminophen were prepared, and improvements in their fluidity by the lubricants were compared. The lubricant effects of TR-FB and HB during tablet punching (pressure transmission ratio, ejection force) were similar to those of Mg-St and were better than those of SSE. When the lubricant content, mixing time, and tabletting pressure were changed, TR-FB® and TR-HB® provided better tablet hardness than Mg-St. TR-FB® and TR-HB® made tablets more disintegratable than Mg-St. When the effects of these lubricants on the stability of acetylsalicylic acid (ASA) were compared, Mg-St promoted its hydrolysis, but TR-FB® or TR-HB® did not affect its stability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 293, Issues 1â2, 11 April 2005, Pages 25-34
Journal: International Journal of Pharmaceutics - Volume 293, Issues 1â2, 11 April 2005, Pages 25-34
نویسندگان
Hiroyuki Aoshima, Atsuo Miyagisnima, Yasuo Nozawa, Yasuyuki Sadzuka, Takashi Sonobe,