کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918888 | 1557561 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro drug release mechanism and drug loading studies of cubic phase gels
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro drug release mechanism and drug loading studies of cubic phase gels In vitro drug release mechanism and drug loading studies of cubic phase gels](/preview/png/9918888.png)
چکیده انگلیسی
Glyceryl monooleate/water cubic phase systems were investigated as drug delivery systems, using salicylic acid as a model drug. The liquid crystalline phases formed by the glyceryl monooleate (GMO)/water systems were characterized by polarizing microscopy. In vitro drug release studies were performed and the influences of initial water content, swelling and drug loading on the drug release properties were evaluated. Water uptake followed second-order swelling kinetics. In vitro release profiles showed Fickian diffusion control and were independent on the initial water content and drug loading, suggesting GMO cubic phase gels suitability for use as drug delivery system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 293, Issues 1â2, 11 April 2005, Pages 241-250
Journal: International Journal of Pharmaceutics - Volume 293, Issues 1â2, 11 April 2005, Pages 241-250
نویسندگان
Marilisa G. Lara, M. Vitória L.B. Bentley, John H. Collett,