کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918955 | 1557564 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synergistic effect of EDTA and boric acid on corneal penetration of CS-088
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synergistic effect of EDTA and boric acid on corneal penetration of CS-088 Synergistic effect of EDTA and boric acid on corneal penetration of CS-088](/preview/png/9918955.png)
چکیده انگلیسی
The corneal penetration of CS-088 was significantly enhanced in the presence of EDTA/boric acid by approximately 1.6-fold. The permeability-enhancing effect of EDTA/boric acid was apparently synergistic and concentration-dependent on both EDTA and boric acid. The penetration of FITC-dextran, a paracellular marker, and electrical resistance of corneal membranes were not affected in the presence of EDTA/boric acid. Furthermore, no enhancing effect of EDTA/boric acid was observed in de-epithelialized corneas, although de-epithelialized corneas exhibited a markedly higher permeability of CS-088 that was 24-fold greater than that for intact corneas. In conclusion, EDTA/boric acid synergistically enhances the transcellular permeability of CS-088 in the outer layer but not in the inner layers of the corneal membrane.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 290, Issues 1â2, 16 February 2005, Pages 83-89
Journal: International Journal of Pharmaceutics - Volume 290, Issues 1â2, 16 February 2005, Pages 83-89
نویسندگان
Takayuki Kikuchi, Masahiko Suzuki, Akira Kusai, Ken Iseki, Hitoshi Sasaki,